依达拉奉联合中成药制剂治疗急性脑梗死大鼠的疗效和安全性评价          下载免费PDF全文

冯君健  周德生 《应用海洋学学报》2019,35(7):142-144

目的：研究依达拉奉联合中成药制剂对急性脑梗死大鼠的疗效比较和安全性评价。方法：将SD大鼠随机分为假手术组、模型组、依达拉奉联合丹红注射液组（A组）、依达拉奉联合血塞通冻干组（B组）、依达拉奉联合醒脑静组（C组）、依达拉奉联合疏血通注射液组（D组），采用线栓法制作大鼠左侧大脑中动脉脑缺血（MCAO）模型，除假手术组外，每组按不同时间点（1、3、5、7d）分为4个亚组，术后各组腹腔注射相应药物，1次/d，分别连续给药1、3、5、7d，模型组、假手术组予以等体积0.9%氯化钠注射液灌胃，观察比较各组大鼠各时间点神经功能缺损评分、脑组织水含量、脑组织梗死体积、安全性评价指标等。结果：模型组与假手术组各时间点的神经功能缺损评分、脑组织水含量、脑组织梗死体积及安全性评价指标中WBC计数、APTT时间比较，差异均具有统计学意义(P＜0.01)；与模型组比较，A、B、C、D组各时间点的神经功能缺损评分及3、5、7d脑组织水含量、脑梗死体积及安全性评价指标中白细胞（WBC）计数、活化部分凝血酶原（APTT）时间均降低，差异均有统计学意义(P＜0.05或P＜0.01)。结论：依达拉奉联合中成药制剂治疗急性脑梗死大鼠疗效显著、可靠安全，并且随治疗时间延长，对缺血缺氧神经元的改善作用越明显。  相似文献   

德令哈13.7m望远镜接收机抗射频干扰研究     

李振强  李积斌  张旭国  单文磊  徐烨  左营喜  张海龙  金风娟  孙继先  逯登荣  巨秉刚 《天文学报》2019,60(3):62-76

在天文观测中,射频干扰会造成假谱,降低数据的可靠性和有效性.射频干扰消减旨在减少干扰信号对射电天文观测的影响,包含器件方面的技术革新和数据处理领域的方法研究.针对德令哈13.7 m望远镜接收机中频部分引入的射频干扰,通过优化中频器件的抗射频干扰能力,提高了接收机的整体抗射频干扰能力,以主动消除方法来减少射频干扰耦合到接收机内部.分析了接收机干扰的传输路径,提出了器件射频干扰的直接耦合系数和器件射频干扰的系统耦合系数的概念,为定位干扰敏感器件并量化干扰引入比重提供了基础.经过抗射频干扰优化后,接收机抗干扰能力改善30 dB左右,望远镜的天文观测效率提高10%以上.  相似文献   

On Limb Observations of Bolides     

Gorkavyi  N. N. 《Solar System Research》2019,53(1):68-74

The LP/OMPS limb sensor of the Suomi satellite detected the atmospheric trace of the Chelyabinsk superbolide with an energy of over 400 kt TNT in 2013. The study of LP/OMPS data shows that it detects several bolides with much less energy each year. The paper considers the cases of observation of three bolides in 2016–2017: on February 6, 2016 (13 kt), March 3, 2016 (0.19 kt), and March 9, 2017 (1 kt). The possibility of improving the detection of bolides using a limb sensor in the form of a microsatellite with an increased number of observation regions along the horizon is discussed. Several such microsatellites will be able to track most of the bodies larger than a meter that burn up in the atmosphere of the Earth or Mars.

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Oxygen and Al‐Mg isotopic compositions of grossite‐bearing refractory inclusions from CO3 chondrites     

Steven B. Simon  Alexander N. Krot  Kazuhide Nagashima 《Meteoritics & planetary science》2019,54(6):1362-1378

The distribution of the short‐lived radionuclide ²⁶Al in the early solar system remains a major topic of investigation in planetary science. Thousands of analyses are now available but grossite‐bearing Ca‐, Al‐rich inclusions (CAIs) are underrepresented in the database. Recently found grossite‐bearing inclusions in CO3 chondrites provide an opportunity to address this matter. We determined the oxygen and magnesium isotopic compositions of individual phases of 10 grossite‐bearing CAIs in the Dominion Range (DOM) 08006 (CO3.0) and DOM 08004 (CO3.1) chondrites. All minerals in DOM 08006 CAIs as well as hibonite, spinel, and pyroxene in DOM 08004 are uniformly ¹⁶O‐rich (Δ¹⁷O = ?25 to ?20‰) but grossite and melilite in DOM 08004 CAIs are not; Δ¹⁷O of grossite and melilite range from ~ ?11 to ~0‰ and from ~ ?23 up to ~0‰, respectively. Even within this small suite, in the two chondrites a bimodal distribution of the inferred initial ²⁶Al/²⁷Al ratios (²⁶Al/²⁷Al)₀ is seen, with four having (²⁶Al/²⁷Al)₀ ≤1.1 × 10^?5 and six having (²⁶Al/²⁷Al)₀ ≥3.7 × 10^?5. Five of the ²⁶Al‐rich CAIs have (²⁶Al/²⁷Al)₀ within error of 4.5 × 10^?5; these values can probably be considered indistinguishable from the “canonical” value of 5.2 × 10^?5 given the uncertainty in the relative sensitivity factor for grossite measured by secondary ion mass spectrometry. We infer that the ²⁶Al‐poor CAIs probably formed before the radionuclide was fully mixed into the solar nebula. All minerals in the DOM 08006 CAIs, as well as spinel, hibonite, and Al‐diopside in the DOM 08004 CAIs retained their initial oxygen isotopic compositions, indicating homogeneity of oxygen isotopic compositions in the nebular region where the CO grossite‐bearing CAIs originated. Oxygen isotopic heterogeneity in CAIs from DOM 08004 resulted from exchange between the initially ¹⁶O‐rich (Δ¹⁷O ~?24‰) melilite and grossite and ¹⁶O‐poor (Δ¹⁷O ~0‰) fluid during hydrothermal alteration on the CO chondrite parent body; hibonite, spinel, and Al‐diopside avoided oxygen isotopic exchange during the alteration. Grossite and melilite that underwent oxygen isotopic exchange avoided redistribution of radiogenic ²⁶Mg and preserved undisturbed internal Al‐Mg isochrons. The Δ¹⁷O of the fluid can be inferred from O‐isotopic compositions of aqueously formed fayalite and magnetite that precipitated from the fluid on the CO parent asteroid. This and previous studies suggest that O‐isotope exchange during fluid–rock interaction affected most CAIs in CO ≥3.1 chondrites.  相似文献   

The constancy of galactic cosmic rays as recorded by cosmogenic nuclides in iron meteorites     

Thomas Smith  David L. Cook  Silke Merchel  Stefan Pavetich  Georg Rugel  Andreas Scharf  Ingo Leya 《Meteoritics & planetary science》2019,54(12):2951-2976

We measured the He, Ne, and Ar isotopic concentrations and the ¹⁰Be, ²⁶Al, ³⁶Cl, and ⁴¹Ca concentrations in 56 iron meteorites of groups IIIAB, IIAB, IVA, IC, IIA, IIB, and one ungrouped. From ⁴¹Ca and ³⁶Cl data, we calculated terrestrial ages indistinguishable from zero for six samples, indicating recent falls, up to 562 ± 86 ka. Three of the studied meteorites are falls. The data for the other 47 irons confirm that terrestrial ages for iron meteorites can be as long as a few hundred thousand years even in relatively humid conditions. The ³⁶Cl‐³⁶Ar cosmic ray exposure (CRE) ages range from 4.3 ± 0.4 Ma to 652 ± 99 Ma. By including literature data, we established a consistent and reliable CRE age database for 67 iron meteorites. The high quality of the CRE ages enables us to study structures in the CRE age histogram more reliably. At first sight, the CRE age histogram shows peaks at about 400 and 630 Ma. After correction for pairing, the updated CRE age histogram comprises 41 individual samples and shows no indications of temporal periodicity, especially not if one considers each iron meteorite group separately. Our study contradicts the hypothesis of periodic GCR intensity variations (Shaviv 2002, 2003), confirming other studies indicating that there are no periodic structures in the CRE age histogram (e.g., Rahmstorf et al. 2004; Jahnke 2005). The data contradict the hypothesis that periodic GCR intensity variations might have triggered periodic Earth climate changes. The ³⁶Cl‐³⁶Ar CRE ages are on average 40% lower than the ⁴¹K‐K CRE ages (e.g., Voshage 1967). This offset can either be due to an offset in the ⁴¹K‐K dating system or due to a significantly lower GCR intensity in the time interval 195–656 Ma compared to the recent past. A 40% lower GCR intensity, however, would have increased the Earth temperature by up to 2 °C, which seems unrealistic and leaves an ill‐defined ⁴¹K‐K CRE age system the most likely explanation. Finally, we present new ²⁶Al/²¹Ne and ¹⁰Be/²¹Ne production rate ratios of 0.32 ± 0.01 and 0.44 ± 0.03, respectively.  相似文献   

Evolution of the Fine Structure of the Matter Distribution of a Free-Falling Droplet in Mixing Liquids     

Chashechkin  Yu. D. 《Izvestiya Atmospheric and Oceanic Physics》2019,55(3):285-294

Izvestiya, Atmospheric and Oceanic Physics - In this paper we study the evolution of the matter distribution pattern of ink droplets falling freely into calm water and forming a cumulative back jet...  相似文献   

中国近海藻毒素及有毒微藻产毒原因种调查研究进展   总被引：2，自引：0，他引：2  

梁玉波  李冬梅  姚敬元  金薇  宫长宝  刘仁沿 《海洋与湖沼》2019,50(3):511-524

麻痹性贝类毒素在我国近海污染问题已十分突出,基本呈现逐年加剧的趋势。20世纪90年代,南海麻痹性贝类毒素污染较重; 21世纪初,北黄海麻痹性贝类毒素污染较重;近几年,渤海和福建近海麻痹性贝类毒素污染较重;可产生麻痹性贝类毒素的微藻有亚历山大藻和裸甲藻等。采用小鼠生物法检测我国近海腹泻性贝类毒素超标率32%左右,采用液相色谱/质谱法检测,仅有3起超标的研究报道;现行小鼠生物法检测腹泻性贝类毒素假阳性问题十分突出,应尽快废除;腹泻性贝类毒素均是脂溶性的,脂溶性海洋生物毒素在我国近海常年可检出,偶有虾夷扇贝毒素和鳍藻毒素超标现象。可产生脂溶性毒素微藻有鳍藻和原甲藻及网状原角藻等。失忆性贝类毒素在我国近海常有检出,但无超标现象;产毒微藻有拟菱形藻等。西加鱼毒素在我国南海污染较重,但毒素标准物质的匮乏,限制了西加鱼毒素的调查研究;至今尚未确定产生西加鱼毒素的微藻。酶联免疫吸附法和液相色谱串联质谱法相结合已成为藻毒素快速准确检测成熟的技术,逐渐代替小鼠生物法和液相色谱法。  相似文献   

Engineering Geophysical Studies in the Black Sea aboard the R/V Ashamba in 2017     

Dmitrevskiy  N. N.  Ananyev  R. A. 《Oceanology》2019,59(2):290-291

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刘公岛海洋牧场底层海水溶解氧浓度的变化特征     

李兆钦  李欣  孙利元  刘子洲  顾艳镇  翟方国  李培良 《海洋与湖沼》2019,50(1):86-99

由于缺乏长期观测资料,前人对山东半岛邻近海域海水溶解氧的时间变化和空间分布特征的研究较少。本文基于威海刘公岛海洋牧场于2016年7月20日至2017年3月14日期间,利用生态环境实时在线观测系统获得的底层海水的温度、盐度、水深、溶解氧数据,分析了该牧场海水溶解氧浓度的时间变化特征及其影响因素,并探讨了低氧灾害发生的可能性。结果表明在观测期间,该牧场海水溶解氧浓度以季节变化为主,冬季最大、夏季最小,其中2月份平均值最高,约为10.86mg/L,8月份平均值最低,约为5.91mg/L。同时海水溶解氧浓度也存在显著的小时变化和日变化,且变化幅度于8月份最大、3月份最小。影响海水溶解氧浓度变化的主要因素是海水温度,溶解氧浓度随着温度的季节性变化而变化。夏季,水体分层会使溶解氧浓度发生大幅度的降低,大风过程对于溶解氧浓度也有一定的影响,通过打破夏季的季节性温跃层使水体发生垂向混合从而为海底提供氧气,但大风过程之后的几天会出现溶解氧浓度降低的现象。本次研究发现刘公岛海洋牧场在观测期间不存在低氧现象。  相似文献   

Late Cambrian microbial build-ups,Llano Area,Central Texas: A three-phase morphological evolution     

Pankaj Khanna  Heath H. Hopson  André W. Droxler  Dylan A. Droxler  Daniel Lehrmann  Brian Kubik  Jacob Proctor  Pulkit Singh  Paul M. Harris 《Sedimentology》2020,67(2):1135-1160

Although Late Cambrian microbial build-ups were recognized in the Point Peak Member of the Wilberns Formation in Central Texas (USA) nearly 70 years ago, only a few studies focused specifically on the build-ups themselves. This study focuses on the interpretation of the regional (15 measured sections described in literature representing an area of 8000 km²) and local (field and drone photogrammetry studies in a 25 km² area from within south Mason County) microbial build-up occurrence, describes their growth phases and details their interactions with the surrounding inter-build-up sediments. The study establishes the occurrence of microbial build-ups in the lower and upper Point Peak members (the Point Peak Member is informally broken up into the lower Point Peak and the upper Point Peak members separated by Plectotrophia zone). The lower Point Peak Member consists of three <1 m thick microbial bioherms and biostrome units, in addition to heterolithic and skeletal/ooid grainstone and packstone beds. One, up to 14 m thick, microbial unit associated with inter-build-up skeletal and ooid grainstone and packstone beds, intercalated with mixed siliciclastic–carbonate silt beds, characterizes the upper Point Peak member. The microbial unit in the upper Point Peak member displays a three-phase growth evolution, from an initial colonization phase on flat based, rip-up clast lenses, to a second aggradation and lateral expansion phase, into a third well-defined capping phase. The ultimate demise of the microbial build-ups is interpreted to have been triggered by an increase of water turbidity caused by a sudden influx of fine siliciclastics. The lower Point Peak member represents inner ramp shallow subtidal and intertidal facies and the upper Point Peak member corresponds to mid-outer ramp subtidal facies. Understanding the morphological architecture and depositional context of these features is of importance for identifying signatures of early life on Earth.  相似文献